The Resilient Science of Flavonoids

The micro-nutrient flavonoids in EVERSPORT simulate exercise in a number of ways that may contribute to increased endurance and resilience.

We fortify each EVERSPORT product with two specific flavonoids called EPICATECHIN & QUERCETIN.

These active bio-nutrients are present in many healthy fruits, vegetables and even tea, cocoa, and coffee. There is a large body of science demonstrating a variety of astonishing links to endurance and resilience.

Exercise is beneficial because it's hard

The reason why exercise can feel difficult is because it stresses our muscles and cardiovascular system. As we accumulate stress through exertion, we feel the effects as fatigue, soreness, and even mental fog.

But the benefit of doing hard things, then recovering and recharging, is that the body adapts. So the next time our muscles, heart, brain and lungs are faced with a similar workload they're a little stronger, more efficient and more resilient to tackle the next challenge.

Rinse and repeat! Over time we increase stamina, fitness, and our ability to rebound and go again.

So what are some of the key adaptations we're targeting to increase resiliency and endurance?

Energy Metabolism

Cardio exercise leads to adaptations inside muscle cells that improve our efficiency and ability to sustain exercise using aerobic metabolism.

This happens when muscle cells respond to strenuous exercise by producing more mitochondria inside each cell. Mitochondria are the sub-cellular structures that help power exercise. The more we have in each muscle cell, the more efficient we become at fueling motion which translates to increased stamina before depleting our energy reserves and fatiguing.

Quercetin & Epicatechin have been shown to stimulate mitochondrial biogenesis in muscle, brain, and heart tissue. This is the process that produces more mitochondria in each cell which also translates to the ability to utilize more oxygen and fat to sustain exercise.

Muscle Growth

During long or strenuous exercise, muscle cells experience micro-damage to their structure. This triggers an inflammatory response that mobilizes immune cells and nutrients to begin the repair process. The outcome is not only restoration of muscle function but also reinforcement of existing muscle fibers, contributing to increased muscle strength, density, and endurance.

Epicatechin has been shown to help reduce the loss of muscle mass, and aid muscle growth.

Blood Flow

As we increase exertion or prolong exercise, our muscles demand more and more metabolic resources. That means increasing the flow of oxygen, water, electrolytes and energy sources in the blood to hard working muscle cells.

Our network of blood vessels are flexible and can expand and contract to meet the demands of exercise just like a gas pedal controls fuel flow to an engine. As we age, the flexibility of this system decreases, gradually restricting our ability to throttle up blood flow when needed. Exercise helps maintain and even increase the functionality of our cardiovascular system.

Epicatechin has been demonstrated to stimulate Nitric Oxide production, a signaling molecule that plays a key role in telling our blood vessels when to expand and increase blood flow to muscles.

Oxidative Stress & Recovery

With cardio exercise, oxidative stress builds up in muscle cells, contributing to inflammation, fatigue and soreness which we often experience "the day after". With regular exercise, we can improve muscle resilience in the face of oxidative stress and pay less of a toll when we are highly active. This translates to increased endurance, making it easier to sustain effort and recover a little faster after exercise.

Quercetin & Epicatechin both have potent antioxidant properties that help muscle cells scrub oxidative stress during & after exercise.

Epicatechin has been shown to help inhibit muscle cell inflammatory signaling, which assists our natural exercise recovery process and helps reduce soreness and fatigue when we over-exert.

Flavonoid References

ENERGY METABOLISM

Craig DM, Ashcroft SP, Belew MY, et al. Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis. Front Physiol. 2015;6:296. doi:10.3389/fphys.2015.00296
Davis JM, Murphy EA, Carmichael MD, Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiology-regulatory Integr Comp Physiology. 2009;296(4):R1071-R1077. doi:10.1152/ajpregu.90925.2008

MUSCLE GROWTH

 Moreno-Ulloa A, Miranda-Cervantes A, Licea-Navarro A, et al. (-)-Epicatechin stimulates mitochondrial biogenesis and cell growth in C2C12 myotubes via the G-protein coupled estrogen receptor. Eur J Pharmacol. 2018;822:95-107. doi:10.1016/j.ejphar.2018.01.014
German IJS, Pomini KT, Andreo JC, Shindo JVTC, Castro MVM, Detregiachi CRP, Araújo AC, Guiguer EL, Fornari Laurindo L, Bueno PCDS, Souza MDSS, Gabaldi M, Barbalho SM, Shinohara AL. New Trends to Treat Muscular Atrophy: A Systematic Review of Epicatechin. Nutrients. 2024 Jan 22;16(2):326. doi: 10.3390/nu16020326. PMID: 38276564; PMCID: PMC10818576.

BLOOD FLOW

Brossette T, Hundsdörfer C, Kröncke KD, Sies H, Stahl W. Direct evidence that (−)-epicatechin increases nitric oxide levels in human endothelial cells. Eur J Nutr. 2011;50(7):595-599. doi:10.1007/s00394-011-0172-9
Steffen Y, Schewe T, Sies H. (–)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase. Biochem Biophys Res Commun. 2007;359(3):828-833. doi:10.1016/j.bbrc.2007.05.200

OXIDATIVE STRESS & RECOVERY

Ramiro-Puig E, Castell M. Cocoa: antioxidant and immunomodulator. Brit J Nutr. 2009;101(7):931-940. doi:10.1017/s0007114508169896
Marika M, Scoditti E, Carluccio MA, Kaltsatou A, Cicchella A. Effect of Cocoa Products and Its Polyphenolic Constituents on Exercise Performance and Exercise-Induced Muscle Damage and Inflammation: A Review of Clinical Trials. Nutrients. 2019;11(7):1471. doi:10.3390/nu11071471
Zbinden-Foncea H, Castro-Sepulveda M, Fuentes J, Speisky H. Effect of Epicatechin on Skeletal Muscle. Curr Med Chem. 2022;29(6):1110-1123. doi:10.2174/0929867329666211217100020

McBrier NM, Vairo GL, Bagshaw D, Lekan JM, Bordi PL, Kris-Etherton PM. Cocoa-Based Protein and Carbohydrate Drink Decreases Perceived Soreness After Exhaustive Aerobic Exercise; A Pragmatic Preliminary Analysis. J Strength Cond Res. 2010;24(8):2203-2210. doi:10.1519/jsc.0b013e3181e4f7f9